abstract：BACKGROUND:The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of Ca2+-permeable alpha-ami...

journal_title：Biological psychiatry

authors： Scheyer AF,Loweth JA,Christian DT,Uejima J,Rabei R,Le T,Dolubizno H,Stefanik MT,Murray CH,Sakas C,Wolf ME

更新日期：2016-11-01 00:00:00

abstract：:Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...

journal_title：Biological psychiatry

authors： Otto MW,Kredlow MA,Smits JAJ,Hofmann SG,Tolin DF,de Kleine RA,van Minnen A,Evins AE,Pollack MH

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:There is evidence of abnormal cerebral dopamine transmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due to acute nicotine abuse or whether they persist with abstinence. We addressed this question by conducting longitudinal positron emission tomography (PET) ex...

journal_title：Biological psychiatry

authors： Rademacher L,Prinz S,Winz O,Henkel K,Dietrich CA,Schmaljohann J,Mohammadkhani Shali S,Schabram I,Stoppe C,Cumming P,Hilgers RD,Kumakura Y,Coburn M,Mottaghy FM,Gründer G,Vernaleken I

更新日期：2016-08-01 00:00:00

abstract：:Children who experience chronic stressors are vulnerable to emotional and physical health problems across the lifespan. This phenomenon raises questions for scientists and clinicians alike. How does adversity get under the skin of the developing child? Through what mechanisms does it confer vulnerability to a heteroge...

journal_title：Biological psychiatry

authors： Nusslock R,Miller GE

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

journal_title：Biological psychiatry

authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology. The receptor is also expressed in other brain areas, and here we examined whether GPR88 function extends beyond striatal-mediated responses. METHODS:We c...

journal_title：Biological psychiatry

authors： Meirsman AC,Le Merrer J,Pellissier LP,Diaz J,Clesse D,Kieffer BL,Becker JA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...

journal_title：Biological psychiatry

authors： Roberts JE,Tonnsen BL,McCary LM,Ford AL,Golden RN,Bailey DB Jr

更新日期：2016-05-15 00:00:00

abstract：BACKGROUND:Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual association...

journal_title：Biological psychiatry

authors： Potier M,Georges F,Brayda-Bruno L,Ladépêche L,Lamothe V,Al Abed AS,Groc L,Marighetto A

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Clinically and biologically, autism spectrum disorder (ASD) is heterogeneous. Unusual patterns of visual preference as indexed by eye tracking are hallmarks; however, whether they can be used to define an early biomarker of ASD as a whole or leveraged to define a subtype is unclear. To begin to examine this ...

journal_title：Biological psychiatry

authors： Pierce K,Marinero S,Hazin R,McKenna B,Barnes CC,Malige A

更新日期：2016-04-15 00:00:00

abstract：:Cannabis use has been reported to increase the risk of developing schizophrenia and to worsen symptoms of the illness. Both of these outcomes might be attributable to the disruption by cannabis of the endogenous cannabinoid system's spatiotemporal regulation of the inhibitory circuitry in the prefrontal cortex that is...

journal_title：Biological psychiatry

authors： Volk DW,Lewis DA

更新日期：2016-04-01 00:00:00

abstract：:Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the fin...

journal_title：Biological psychiatry

authors： Gage SH,Hickman M,Zammit S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently...

journal_title：Biological psychiatry

authors： Morris LS,Kundu P,Baek K,Irvine MA,Mechelmans DJ,Wood J,Harrison NA,Robbins TW,Bullmore ET,Voon V

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects indu...

journal_title：Biological psychiatry

authors： Tozzi A,de Iure A,Bagetta V,Tantucci M,Durante V,Quiroga-Varela A,Costa C,Di Filippo M,Ghiglieri V,Latagliata EC,Wegrzynowicz M,Decressac M,Giampà C,Dalley JW,Xia J,Gardoni F,Mellone M,El-Agnaf OM,Ardah MT,Puglisi-A

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Despite cognitive function impairment in depression, its relationship to treatment outcome is not well understood. Here, we examined whether pretreatment activation of cortical circuitry during test of cognitive functions predicts outcomes for three commonly used antidepressants. METHODS:Eighty medication-f...

journal_title：Biological psychiatry

authors： Gyurak A,Patenaude B,Korgaonkar MS,Grieve SM,Williams LM,Etkin A

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:There is amassing evidence that risky decision-making in bipolar disorder is related to reward-based differences in frontostriatal regions. However, the roles of early attentional and later cognitive processes remain unclear, limiting theoretical understanding and development of targeted interventions. METH...

journal_title：Biological psychiatry

authors： Mason L,Trujillo-Barreto NJ,Bentall RP,El-Deredy W

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3 trials. METHODS:Two randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in nonelderly (18-64 years) and elderly (≥65 years) patients with insomnia. Suvorexant doses of 4...

journal_title：Biological psychiatry

authors： Herring WJ,Connor KM,Ivgy-May N,Snyder E,Liu K,Snavely DB,Krystal AD,Walsh JK,Benca RM,Rosenberg R,Sangal RB,Budd K,Hutzelmann J,Leibensperger H,Froman S,Lines C,Roth T,Michelson D

更新日期：2016-01-15 00:00:00

abstract：:Obsessive-compulsive disorder (OCD) affects 2%-3% of the population worldwide and can cause significant distress and disability. Substantial challenges remain in the field of OCD research and therapeutics. Approved interventions alleviate symptoms only partially, with 30%-40% of patients being resistant to treatment. ...

journal_title：Biological psychiatry

authors： Monteiro P,Feng G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) co-occurs with substance use disorders at high rates, but the neurobiological basis of this relationship is largely unknown. PTSD and drug addiction each involve dysregulation of brain reward circuitry; therefore, the identification of pathology of the mesolimbic dopamine...

journal_title：Biological psychiatry

authors： Enman NM,Arthur K,Ward SJ,Perrine SA,Unterwald EM

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Fear learning in stressful situations is highly adaptive for survival by steering behavior in subsequent situations, but fear learning can become disproportionate in vulnerable individuals. Despite the potential clinical significance, the mechanism by which stress modulates fear learning is poorly understood...

journal_title：Biological psychiatry

authors： Vogel S,Klumpers F,Kroes MC,Oplaat KT,Krugers HJ,Oitzl MS,Joëls M,Fernández G

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...

journal_title：Biological psychiatry

authors： Sui J,Pearlson GD,Du Y,Yu Q,Jones TR,Chen J,Jiang T,Bustillo J,Calhoun VD

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Adenosine A2A receptors (A2AR) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive processes associated with schizophrenia. Because astroglial A2AR regulate the availability of glutamate, we hypothesized that they might play an unprecedented role in some ...

journal_title：Biological psychiatry

authors： Matos M,Shen HY,Augusto E,Wang Y,Wei CJ,Wang YT,Agostinho P,Boison D,Cunha RA,Chen JF

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Sleep disturbance is associated with activation of systemic and cellular inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes. Whether treatments that target insomnia-related complaints might reverse these markers of inflammation in older adults with insomnia is not kno...

journal_title：Biological psychiatry

authors： Irwin MR,Olmstead R,Breen EC,Witarama T,Carrillo C,Sadeghi N,Arevalo JM,Ma J,Nicassio P,Bootzin R,Cole S

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...

journal_title：Biological psychiatry

authors： Cohn MD,Veltman DJ,Pape LE,van Lith K,Vermeiren RR,van den Brink W,Doreleijers TA,Popma A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:After no research in humans for >40 years, there is renewed interest in using lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no modern studies on the subjective and autonomic effects of LSD, and its endocrine effects are unknown. In animals, LSD disrupts prepulse in...

journal_title：Biological psychiatry

authors： Schmid Y,Enzler F,Gasser P,Grouzmann E,Preller KH,Vollenweider FX,Brenneisen R,Müller F,Borgwardt S,Liechti ME

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:No opioid receptor, mu 1 (OPRM1) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been conclusively associated with heroin/other opioid addiction, despite their biological plausibility. We used evidence of polymorphisms altering OPRM1 expression in normal huma...

journal_title：Biological psychiatry

authors： Hancock DB,Levy JL,Gaddis NC,Glasheen C,Saccone NL,Page GP,Hulse GK,Wildenauer D,Kelty EA,Schwab SG,Degenhardt L,Martin NG,Montgomery GW,Attia J,Holliday EG,McEvoy M,Scott RJ,Bierut LJ,Nelson EC,Kral AH,Johnson EO

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...

journal_title：Biological psychiatry

authors： Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role in maintaining dendritic structure through its interaction with microtubules. In schizophrenia (Sz), numerous studies have revealed that the typically robust immunoreactivity (IR) of MAP2 is significantly reduced across several c...

journal_title：Biological psychiatry

authors： Shelton MA,Newman JT,Gu H,Sampson AR,Fish KN,MacDonald ML,Moyer CE,DiBitetto JV,Dorph-Petersen KA,Penzes P,Lewis DA,Sweet RA

更新日期：2015-09-15 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is a stress-related psychiatric disorder that is thought to emerge from complex interactions among traumatic events and multiple genetic factors. Epigenetic regulation lies at the heart of these interactions and mediates the lasting effects of the environment on gene regulation. An...

journal_title：Biological psychiatry

authors： Zannas AS,Provençal N,Binder EB

更新日期：2015-09-01 00:00:00

abstract：:The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings showing reliably increas...

journal_title：Biological psychiatry

authors： Hamilton JP,Farmer M,Fogelman P,Gotlib IH

更新日期：2015-08-15 00:00:00

abstract：BACKGROUND:The neural projections from the infralimbic region of the prefrontal cortex to the amygdala are important for the maintenance of conditioned fear extinction. Neurons in this pathway exhibit a unique pattern of structural plasticity that is sex-dependent, but the relationship between the morphologic character...

journal_title：Biological psychiatry

authors： Gruene TM,Roberts E,Thomas V,Ronzio A,Shansky RM

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) ...

journal_title：Biological psychiatry

authors： Meziane H,Schaller F,Bauer S,Villard C,Matarazzo V,Riet F,Guillon G,Lafitte D,Desarmenien MG,Tauber M,Muscatelli F

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Patients with autism have been often reported to have a smaller corpus callosum (CC) than control subjects. METHODS:We conducted a meta-analysis of the literature, analyzed the CC in 694 subjects of the Autism Brain Imaging Data Exchange project, and performed computer simulations to study the effect of dif...

journal_title：Biological psychiatry

authors： Lefebvre A,Beggiato A,Bourgeron T,Toro R

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging. METHODS:Given that scalp hair follicles are easily accessible and, like the brain, are derived from the ectoderm, expressions of messenger RNA (mRNA) and microRNA in the organ were examined between schizoph...

journal_title：Biological psychiatry

authors： Maekawa M,Yamada K,Toyoshima M,Ohnishi T,Iwayama Y,Shimamoto C,Toyota T,Nozaki Y,Balan S,Matsuzaki H,Iwata Y,Suzuki K,Miyashita M,Kikuchi M,Kato M,Okada Y,Akamatsu W,Mori N,Owada Y,Itokawa M,Okano H,Yoshikawa T

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Coping strategy impacts susceptibility to psychosocial stress. The locus coeruleus (LC) and dorsal raphe (DR) are monoamine nuclei implicated in stress-related disorders. Our goal was to identify genes in these nuclei that distinguish active and passive coping strategies in response to social stress. METHOD...

journal_title：Biological psychiatry

authors： Wood SK,Wood CS,Lombard CM,Lee CS,Zhang XY,Finnell JE,Valentino RJ

更新日期：2015-07-01 00:00:00

abstract：:Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts th...

journal_title：Biological psychiatry

authors： Fenton AA

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:The neurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates small GTPases of the Ras family. METHODS:We assessed alcohol-related behaviors including alcohol sensitivity, dependent and nondependent drinking, and basal and alcohol-induced gamma-aminobutyric acid (GABA...

journal_title：Biological psychiatry

authors： Repunte-Canonigo V,Herman M,Kawamura T,Kranzler HR,Sherva R,Gelernter J,Farrer LA,Roberto M,Sanna PP

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Stressors negatively impact emotional state and drive drug seeking, in part, by modulating the activity of the mesolimbic dopamine system. Unfortunately, the rapid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well characterized. In a series of experiments, we scruti...

journal_title：Biological psychiatry

authors： Twining RC,Wheeler DS,Ebben AL,Jacobsen AJ,Robble MA,Mantsch JR,Wheeler RA

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Reduction of precuneus choline acetyltransferase activity co-occurs with greater beta-amyloid (Aβ) in Alzheimer's disease (AD). Whether this cholinergic deficit is associated with alteration in nerve growth factor (NGF) signaling and its relation to Aβ plaque and neurofibrillary tangle (NFT) pathology during...

journal_title：Biological psychiatry

authors： Perez SE,He B,Nadeem M,Wuu J,Scheff SW,Abrahamson EE,Ikonomovic MD,Mufson EJ

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Depression and stress promote obesity. This study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals. METHODS:This double-blind, randomized, crossover study included serial assessments of resting energy expenditur...

journal_title：Biological psychiatry

authors： Kiecolt-Glaser JK,Habash DL,Fagundes CP,Andridge R,Peng J,Malarkey WB,Belury MA

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Neuronal activity at gamma frequency is impaired in schizophrenia (SZ) and is considered critical for cognitive performance. Such impairments are thought to be due to reduced N-methyl-D-aspartate receptor (NMDAR)-mediated inhibition from parvalbumin interneurons, rather than a direct role of impaired NMDAR s...

journal_title：Biological psychiatry

authors： Tatard-Leitman VM,Jutzeler CR,Suh J,Saunders JA,Billingslea EN,Morita S,White R,Featherstone RE,Ray R,Ortinski PI,Banerjee A,Gandal MJ,Lin R,Alexandrescu A,Liang Y,Gur RE,Borgmann-Winter KE,Carlson GC,Hahn CG,Siegel

更新日期：2015-03-15 00:00:00